POMT2

Across TCGA patient cohorts, POMT2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POMT2-associated genes across cancer lineages are Caspase-7-cleavedD198, mTOR_pS2448, and 4E-BP1. Each is linked with POMT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POMT2-to-partner and partner-to-POMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by POMT2-low versus POMT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMT2→partner) and Y-score (partner→POMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.659	+3.459	.002	.005	3	3
UCEC	mTOR_pS2448 →	-0.116	-3.446	.031	.005	3	2
UCEC	4E-BP1 →	+0.316	+2.145	.001	.009	3	2
UCEC	14-3-3_beta →	-0.092	-3.558	.010	.002	3	1
UCEC	eEF2 →	+0.303	+1.700	.018	.042	3	1
UCEC	EGFR_pY1068 →	-0.193	-1.584	.032	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by POMT2 expression — UCEC

Explore this box plot interactively →