POMT2

Across TCGA pan-cancer cohorts, POMT2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of POMT2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POMT2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POMT2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where POMT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POMT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.066	<.001	12	view →
LIHC	Female	II,III,IV	+1.154	<.001	9	view →
THCA	Male	III,IV	−0.779	<.001	9	view →
KIRP	Male	II,III,IV	+0.587	<.001	9	view →
BLCA	Female	All	+0.838	<.001	7	view →
LUSC	Male	II,III,IV	+0.583	<.001	7	view →
LUAD	All	II,III,IV	+0.441	<.001	7	view →
COAD	Female	II,III,IV	+0.415	<.001	7	view →
UCEC	All	All	+0.481	.008	6	view →
CHOL	Male	All	+2.066	<.001	5	view →
STAD	Male	II,III,IV	+0.828	.002	5	view →
ESCA	All	All	+0.672	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

POMT2–HNSC

Open the HNSC breakdown →