POMT2

Across TCGA cell cohorts, POMT2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible POMT2-associated genes across cancer lineages are MRAP, HTN3, and IQCF5. Each is linked with POMT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POMT2-to-partner and partner-to-POMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRAP grouped by POMT2-low versus POMT2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMT2→partner) and Y-score (partner→POMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	HTN3 →	+0.079	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	SLC5A8 →	+0.012	+4.736	<.001	.009	3	1
CNS	PRORY →	+1.151	+5.044	<.001	.001	3	1
CNS	BTNL2 →	+0.034	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MRAP by POMT2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →