POMGNT1

Across TCGA cell cohorts, POMGNT1 mutation is significantly associated with the mutation status of many other genes, with 3,335 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POMGNT1-associated genes across cancer lineages are PDE4A, SAP130, and ZNF205. Each is linked with POMGNT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both POMGNT1-to-partner and partner-to-POMGNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE4A grouped by POMGNT1-low versus POMGNT1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMGNT1→partner) and Y-score (partner→POMGNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PDE4A →	+4.954	+4.392	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	SAP130 →	+4.954	+4.392	.008	.008	1	4
LARGE_INTESTINE	ZNF205 →	+2.321	+2.146	.008	.008	1	4
BREAST	RNF20 →	+4.857	+4.297	.009	.009	1	3
UPPER_AERODIGESTIVE_TRACT	CTNNA1 →	+4.954	+4.392	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	TCF7 →	+4.954	+4.392	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,335 associations by consensus.

PDE4A by POMGNT1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →