POM121C

Across TCGA patient cohorts, POM121C mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POM121C-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and eIF4E. Each is linked with POM121C in more than 2 cancer types. Because this analysis shows association rather than direction, both POM121C-to-partner and partner-to-POM121C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by POM121C-low versus POM121C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121C→partner) and Y-score (partner→POM121C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.248	+2.906	.001	.001	3	3
UCEC	Cyclin-B1 →	+0.434	+1.925	.007	.004	3	3
UCEC	eIF4E →	+0.134	+2.087	.027	.005	3	2
UCEC	eIF4G →	+0.194	+1.584	.030	.032	3	2
UCEC	Ku80 →	+0.250	+1.361	<.001	.004	3	2
UCEC	MSH2 →	-0.176	-1.382	.008	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

4E-BP1 by POM121C expression — UCEC

Explore this box plot interactively →