POM121C

Across TCGA cell cohorts, POM121C mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POM121C-associated genes across cancer lineages are MAPK7, CEACAM4, and OR2L5. Each is linked with POM121C in more than 1 cancer types. Because this analysis shows association rather than direction, both POM121C-to-partner and partner-to-POM121C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK7 grouped by POM121C-low versus POM121C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121C→partner) and Y-score (partner→POM121C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAPK7 →	+0.598	+3.364	.003	.002	3	2
PANCREAS	CEACAM4 →	+0.046	+4.237	<.001	.006	3	1
PANCREAS	OR2L5 →	+0.005	+4.614	<.001	.004	3	1
BLOOD_Leukemia	DOK5 →	+0.077	+2.490	<.001	.008	3	1
BLOOD_Leukemia	PRLHR →	+0.007	+2.979	<.001	.007	3	1
BLOOD_Leukemia	SCGB2A1 →	+0.031	+3.616	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

MAPK7 by POM121C expression — LARGE_INTESTINE

Explore this box plot interactively →