Across TCGA patient cohorts, POM121 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POM121-associated genes across cancer lineages are MSH6, mTOR_pS2448, and Notch1. Each is linked with POM121 in more than 1 cancer types. Because this analysis shows association rather than direction, both POM121-to-partner and partner-to-POM121 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121→partner) and Y-score (partner→POM121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.329	-2.662	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.097	-1.489	.017	.025	3	2
UCEC	Notch1 →	+0.099	+1.598	.009	.009	3	2
UCEC	ARID1A →	-0.121	-2.222	.015	.009	3	2
UCEC	TFRC →	+0.361	+2.415	.012	.002	3	2
UCEC	BRCA2 →	-0.088	-1.541	.012	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

POM121 survival (RNA) · tumor vs normal (RNA) · all POM121 data types