POLRMT

Across TCGA patient cohorts, POLRMT protein abundance is significantly associated with the RNA expression of many other genes, with 14,445 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible POLRMT-associated genes across cancer lineages are SORBS2, JAM2, and NUF2. Each is linked with POLRMT in more than 5 cancer types. Because this analysis shows association rather than direction, both POLRMT-to-partner and partner-to-POLRMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLRMT versus SORBS2 in LUAD, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLRMT→partner) and Y-score (partner→POLRMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SORBS2 →	-1.163	-0.300	<.001	.003	3	6
BRCA	JAM2 →	-0.705	-0.452	<.001	<.001	3	6
LSCC	NUF2 →	+0.896	+0.482	<.001	<.001	3	6
UCEC	CDCA5 →	+1.227	+0.431	<.001	<.001	3	6
UCEC	CDC25A →	+0.806	+0.331	<.001	<.001	3	6
UCEC	PBK →	+1.165	+0.347	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,445 associations by consensus.

POLRMT vs SORBS2 — LUAD

Explore this scatter interactively →