POLRMT

Across TCGA patient cohorts, POLRMT mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLRMT-associated genes across cancer lineages are eIF4E, ATM, and MSH6. Each is linked with POLRMT in more than 2 cancer types. Because this analysis shows association rather than direction, both POLRMT-to-partner and partner-to-POLRMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by POLRMT-low versus POLRMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLRMT→partner) and Y-score (partner→POLRMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.176	+3.335	.018	.005	3	3
UCEC	ATM →	-0.480	-2.000	.002	.003	3	3
UCEC	MSH6 →	-0.403	-1.896	<.001	.015	3	2
COAD	Mre11 →	+0.118	+3.000	.013	.034	3	2
COAD	RAD51 →	+0.167	+3.169	.008	.017	3	2
COAD	Chk1 →	+0.286	+2.008	.001	.018	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by POLRMT expression — UCEC

Explore this box plot interactively →