POLRMT

Across TCGA cell cohorts, POLRMT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,135 significant associations in total. BONE shows the largest number of these associations.

The most reproducible POLRMT-associated GO terms across cancer lineages are Cytoplasm protein quality control by the ubiquitin-proteasome system, Cytoplasm protein quality control, and Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with POLRMT in more than 14 cancer types. Because this analysis shows association rather than direction, both POLRMT-to-partner and partner-to-POLRMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasm protein quality control by the ubiquitin-proteasome system grouped by POLRMT-low versus POLRMT-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLRMT→partner) and Y-score (partner→POLRMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.151	+0.880	<.001	<.001	3	15
STOMACH	Cytoplasm protein quality control →	+0.157	+0.960	<.001	<.001	3	14
PANCREAS	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.147	+0.732	<.001	<.001	3	12
STOMACH	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.070	+0.656	<.001	.002	3	11
STOMACH	Electron transport coupled proton transport →	+0.070	+0.656	<.001	.002	3	11
BLOOD_Lymphoma	rRNA pseudouridine synthesis →	+0.086	+0.515	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,135 associations by consensus.

Cytoplasm protein quality control by the ubiquitin-proteasome system by POLRMT expression — STOMACH

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