POLR3K

Across TCGA patient cohorts, POLR3K protein abundance is significantly associated with the RNA expression of many other genes, with 7,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3K-associated genes across cancer lineages are UQCRC2, E4F1, and RSL1D1. Each is linked with POLR3K in more than 3 cancer types. Because this analysis shows association rather than direction, both POLR3K-to-partner and partner-to-POLR3K results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR3K versus UQCRC2 in UCEC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3K→partner) and Y-score (partner→POLR3K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UQCRC2 →	+0.865	+0.352	<.001	<.001	3	4
BRCA	E4F1 →	+0.850	+0.311	<.001	.002	3	4
UCEC	RSL1D1 →	+0.547	+0.248	<.001	<.001	3	4
UCEC	ACTR5 →	+0.877	+0.304	<.001	<.001	3	3
BRCA	AXIN1 →	+0.714	+0.314	<.001	<.001	3	3
BRCA	ZNF500 →	+0.633	+0.347	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,249 associations by consensus.

POLR3K vs UQCRC2 — UCEC

Explore this scatter interactively →