POLR3K

Across TCGA patient cohorts, POLR3K mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible POLR3K-associated genes across cancer lineages are RNU6-79P, RNU4-75P, and RNU4-16P. Each is linked with POLR3K in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3K-to-partner and partner-to-POLR3K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-79P grouped by POLR3K-low versus POLR3K-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3K→partner) and Y-score (partner→POLR3K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-79P →	+0.502	+5.337	<.001	.006	3	1
LUSC	RNU4-75P →	+0.495	+5.474	<.001	.005	3	1
LUSC	RNU4-16P →	+0.717	+6.733	<.001	<.001	3	1
LUSC	RNU6-114P →	+0.444	+5.404	<.001	.005	3	1
LUSC	MIR1229 →	+0.616	+5.706	<.001	.003	3	1
LUSC	RNU6-1086P →	+0.833	+5.151	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

RNU6-79P by POLR3K expression — LUSC

Explore this box plot interactively →