POLR3H

Across TCGA patient cohorts, POLR3H mutation is significantly associated with the RNA expression of many other genes, with 2,511 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3H-associated genes across cancer lineages are TRAJ11, RNU6-332P, and BRD9P1. Each is linked with POLR3H in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3H-to-partner and partner-to-POLR3H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ11 grouped by POLR3H-low versus POLR3H-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3H→partner) and Y-score (partner→POLR3H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ11 →	+0.888	+4.543	.001	.005	3	2
LGG	RNU6-332P →	+0.308	+7.977	<.001	.007	3	2
BLCA	BRD9P1 →	+0.025	+4.455	<.001	.005	3	2
BLCA	MIR4494 →	+0.286	+3.214	.006	.004	3	2
UCEC	CDH12P2 →	+0.029	+4.308	<.001	.003	3	2
UCEC	RN7SKP132 →	+0.103	+3.374	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,511 associations by consensus.

TRAJ11 by POLR3H expression — COAD

Explore this box plot interactively →