POLR3H

Across TCGA pan-cancer cohorts, POLR3H RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of POLR3H’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where POLR3H RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR3H is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where POLR3H tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3H RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.851	<.001	11	view →
THCA	Male	IV	−1.043	<.001	10	view →
HNSC	Male	All	+0.648	<.001	10	view →
LIHC	Male	All	+1.046	<.001	9	view →
KICH	All	All	−0.661	<.001	8	view →
LUAD	Male	II,III,IV	−1.004	<.001	7	view →
STAD	Male	II,III,IV	+0.834	<.001	6	view →
KIRP	All	All	−0.470	<.001	5	view →
KIRC	Female	All	+0.312	.004	5	view →
CHOL	Male	All	+1.785	<.001	3	view →
LUSC	Male	All	−0.313	.013	2	view →
PRAD	All	All	+0.283	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

POLR3H–COAD

Open the COAD breakdown →