POLR3H

Across TCGA patient cohorts, POLR3H mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3H-associated genes across cancer lineages are Fibronectin, Ku80, and Notch1. Each is linked with POLR3H in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3H-to-partner and partner-to-POLR3H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by POLR3H-low versus POLR3H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3H→partner) and Y-score (partner→POLR3H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.285	-2.312	.042	.034	3	1
UCEC	Ku80 →	+0.253	+2.235	.011	.006	3	1
UCEC	Notch1 →	+0.191	+2.906	.001	.001	3	1
UCEC	PCNA →	+0.184	+2.321	.045	.034	3	1
UCEC	PKC-delta_pS664 →	-0.107	-3.312	.035	.010	3	1
UCEC	Rab25 →	-0.513	-2.999	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Fibronectin by POLR3H expression — UCEC

Explore this box plot interactively →