POLR3H

Across TCGA cell cohorts, POLR3H mutation is significantly associated with the mutation status of many other genes, with 147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR3H-associated genes across cancer lineages are ESAM, RBM23, and ORC5. Each is linked with POLR3H in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3H-to-partner and partner-to-POLR3H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESAM grouped by POLR3H-low versus POLR3H-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3H→partner) and Y-score (partner→POLR3H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ESAM →	+4.523	+5.087	.006	.006	1	2
STOMACH	RBM23 →	+4.807	+4.807	.008	.008	1	2
STOMACH	ORC5 →	+4.807	+4.807	.008	.008	1	2
LARGE_INTESTINE	PDK2 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	SYT1 →	+5.523	+5.523	.003	.003	1	1
LARGE_INTESTINE	IFI35 →	+4.523	+5.087	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

ESAM by POLR3H expression — LARGE_INTESTINE

Explore this box plot interactively →