POLR3GL

Across TCGA pan-cancer cohorts, POLR3GL Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated POLR3GL data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher POLR3GL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POLR3GL expression acts as an unfavorable survival marker.

LGG and SCLC are the cancer types where POLR3GL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.250	0.830	.001	12	view →
SCLC	OS	Median	All	0.055	0.708	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

POLR3GL–LGG (OS)

Open the LGG breakdown →