POLR3F

Across TCGA pan-cancer cohorts, POLR3F mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of POLR3F’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where POLR3F mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLR3F is over-expressed in tumor.

LUAD, LSCC, and HNSC are the cancer types where POLR3F tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3F mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+0.387	<.001	8	view →
LSCC	Male	II,III,IV	+0.186	<.001	6	view →
HNSC	All	All	+0.126	.001	6	view →
CCRCC	All	III,IV	+0.115	.004	3	view →
COAD	Female	All	+0.150	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

POLR3F–LUAD

Open the LUAD breakdown →