POLR3F

Across TCGA pan-cancer cohorts, POLR3F RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated POLR3F data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher POLR3F RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR3F expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

LIHC, MESO, and KIRC are the cancer types where POLR3F RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.450	0.637	<.001	94	view →
MESO	OS	Quartile	All	0.390	0.696	.001	43	view →
KIRC	DFS	Median	All	0.722	0.512	.001	30	view →
CESC	DFS	Tertile	IV	0.270	0.718	.010	24	view →
KICH	DFS	Quartile	III,IV	0.179	1.000	.007	21	view →
SCLC	OS	Tertile	All	0.239	0.952	.004	19	view →
PAAD	OS	Quartile	All	0.558	0.165	.001	15	view →
THYM	OS	Tertile	II,III,IV	0.909	0.618	.023	12	view →
ACC	DFS	Median	All	0.547	0.770	.006	11	view →
SKCM	DFS	Quartile	All	0.238	0.123	.001	8	view →
SARC	OS	Median	All	0.680	0.845	.013	8	view →
THCA	OS	Quartile	II,III,IV	0.707	0.938	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

POLR3F–LIHC (DFS)

Open the LIHC breakdown →