POLR3F

Across TCGA patient cohorts, POLR3F mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3F-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and EGFR_pY1068. Each is linked with POLR3F in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3F-to-partner and partner-to-POLR3F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by POLR3F-low versus POLR3F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3F→partner) and Y-score (partner→POLR3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.583	+3.341	.029	.005	3	2
UCEC	eEF2 →	+0.516	+2.000	.001	.030	3	1
UCEC	EGFR_pY1068 →	-0.397	-3.700	<.001	.001	3	1
UCEC	eIF4E →	+0.229	+2.700	.015	.006	3	1
UCEC	A-Raf_pS299 →	-0.184	-2.321	<.001	.034	3	1
UCEC	ERK2 →	+0.263	+2.000	.002	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Caspase-7-cleavedD198 by POLR3F expression — UCEC

Explore this box plot interactively →