POLR3E

Across TCGA pan-cancer cohorts, POLR3E mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of POLR3E’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where POLR3E mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLR3E is over-expressed in tumor.

LUAD, LSCC, and HNSC are the cancer types where POLR3E tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3E mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+0.516	<.001	9	view →
LSCC	Female	II,III,IV	+0.431	<.001	9	view →
HNSC	All	III,IV	+0.162	<.001	8	view →
CCRCC	Male	All	+0.129	<.001	7	view →
COAD	All	II,III,IV	+0.186	.025	3	view →
PDAC	All	All	+0.124	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

POLR3E–LUAD

Open the LUAD breakdown →