POLR3E

Across TCGA pan-cancer cohorts, POLR3E RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated POLR3E data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher POLR3E RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR3E expression acts as an unfavorable survival marker, although some lineages such as BRCA and READ show a favorable association.

KIRP, BRCA, and READ are the cancer types where POLR3E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.374	0.684	.007	60	view →
BRCA	OS	Tertile	III,IV	0.918	0.716	<.001	53	view →
READ	OS	Median	All	0.886	0.500	.001	46	view →
LGG	DFS	Median	All	0.648	0.826	<.001	45	view →
LIHC	DFS	Quartile	All	0.417	0.584	.002	38	view →
BLCA	DFS	Tertile	All	0.190	0.477	.009	28	view →
CESC	DFS	Quartile	All	0.732	0.869	.009	24	view →
LUSC	DFS	Tertile	III,IV	0.448	0.961	.007	24	view →
HNSC	OS	Quartile	III,IV	0.596	0.908	.006	22	view →
ACC	DFS	Tertile	III,IV	0.579	0.086	<.001	22	view →
GBM	DFS	Tertile	All	0.470	0.191	.002	15	view →
SKCM	DFS	Tertile	III,IV	0.145	0.484	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

POLR3E–KIRP (DFS)

Open the KIRP breakdown →