POLR3E

Across TCGA patient cohorts, POLR3E mutation is significantly associated with the RNA expression of many other genes, with 3,640 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3E-associated genes across cancer lineages are SAR1B, NUDCD2, and ZBTB8OS. Each is linked with POLR3E in more than 2 cancer types. Because this analysis shows association rather than direction, both POLR3E-to-partner and partner-to-POLR3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAR1B grouped by POLR3E-low versus POLR3E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3E→partner) and Y-score (partner→POLR3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAR1B →	+0.661	+3.058	<.001	<.001	3	3
UCEC	NUDCD2 →	+0.451	+2.223	.001	<.001	3	3
SKCM	ZBTB8OS →	+0.466	+3.384	.002	.004	3	3
UCEC	ERO1B →	+0.776	+2.534	<.001	<.001	3	3
UCEC	LACTB →	+0.723	+3.743	<.001	<.001	3	3
SKCM	DNAJC1 →	+0.713	+3.632	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,640 associations by consensus.

SAR1B by POLR3E expression — UCEC

Explore this box plot interactively →