POLR3E

Across TCGA patient cohorts, POLR3E mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3E-associated genes across cancer lineages are ATM, c-Met, and EGFR_pY1173. Each is linked with POLR3E in more than 2 cancer types. Because this analysis shows association rather than direction, both POLR3E-to-partner and partner-to-POLR3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by POLR3E-low versus POLR3E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3E→partner) and Y-score (partner→POLR3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.389	-1.584	.017	.019	3	3
SKCM	c-Met →	-0.193	-3.152	.015	.019	3	2
COAD	EGFR_pY1173 →	+0.116	+3.042	.019	.018	3	2
COAD	eIF4E →	+0.225	+3.025	.014	.019	3	2
UCEC	MSH2 →	-0.304	-3.781	<.001	<.001	3	2
COAD	MSH6 →	-0.743	-2.974	<.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by POLR3E expression — UCEC

Explore this box plot interactively →