POLR3E

Across TCGA cell cohorts, POLR3E RNA expression is significantly associated with the go_rna of many other GO terms, with 5,246 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLR3E-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cell PML body, Transcription initiation at RNA polymerase I promoter, and Negative regulation of DNA-templated transcription, elongation. Each is linked with POLR3E in more than 14 cancer types. Because this analysis shows association rather than direction, both POLR3E-to-partner and partner-to-POLR3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cell PML body grouped by POLR3E-low versus POLR3E-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3E→partner) and Y-score (partner→POLR3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Symbiont-mediated disruption of host cell PML body →	+0.127	+0.876	<.001	<.001	3	15
BONE	Transcription initiation at RNA polymerase I promoter →	+0.137	+1.064	<.001	.001	3	15
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.140	+1.003	.001	.001	3	14
LIVER	mRNA alternative polyadenylation →	+0.101	+0.617	<.001	.005	2	15
BONE	rRNA pseudouridine synthesis →	+0.137	+0.940	<.001	.002	3	14
BLOOD_Lymphoma	Mitochondrial ribosome assembly →	+0.113	+1.208	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,246 associations by consensus.

Symbiont-mediated disruption of host cell PML body by POLR3E expression — BREAST

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