POLR3E

Across TCGA cell cohorts, POLR3E mutation is significantly associated with the RNA expression of many other genes, with 498 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR3E-associated genes across cancer lineages are APOL5, PDCL2, and SLC32A1. Each is linked with POLR3E in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3E-to-partner and partner-to-POLR3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by POLR3E-low versus POLR3E-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3E→partner) and Y-score (partner→POLR3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.012	+4.060	.002	.003	3	2
LARGE_INTESTINE	PDCL2 →	+0.155	+3.711	.001	<.001	3	2
BLOOD_Leukemia	SLC32A1 →	+0.990	+3.901	<.001	.006	3	1
BLOOD_Leukemia	KLRD1 →	+0.156	+3.769	<.001	.008	3	1
BLOOD_Leukemia	CLDN8 →	+0.012	+4.234	<.001	.003	3	1
BLOOD_Leukemia	DCLK3 →	+0.263	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 498 associations by consensus.

APOL5 by POLR3E expression — BLOOD_Leukemia

Explore this box plot interactively →