POLR3D

Across TCGA pan-cancer cohorts, POLR3D mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLR3D data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher POLR3D mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated POLR3D expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and GBM are the cancer types where POLR3D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.973	0.711	.001	39	view →
LSCC	DFS	Median	All	0.803	0.626	.021	10	view →
GBM	OS	Tertile	All	0.673	0.332	.011	8	view →
PDAC	OS	Median	IV	0.836	0.491	.024	5	view →
HNSC	DFS	Quartile	II,III,IV	0.661	0.880	.033	4	view →
CCRCC	DFS	Quartile	All	0.909	0.589	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLR3D–LUAD (OS)

Open the LUAD breakdown →