POLR3D

Across TCGA pan-cancer cohorts, POLR3D mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of POLR3D’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where POLR3D mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLR3D is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where POLR3D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.301	<.001	9	view →
LUAD	Male	III,IV	+0.404	<.001	8	view →
CCRCC	Male	All	+0.127	<.001	6	view →
PDAC	All	All	−0.222	.021	2	view →
COAD	All	II,III,IV	+0.172	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

POLR3D–LSCC

Open the LSCC breakdown →