Across TCGA patient cohorts, POLR3C protein abundance is significantly associated with the RNA expression of many other genes, with 14,714 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLR3C-associated genes across cancer lineages are GAS5, EEF1AKNMT, and SETDB1. Each is linked with POLR3C in more than 5 cancer types. Because this analysis shows association rather than direction, both POLR3C-to-partner and partner-to-POLR3C results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3C→partner) and Y-score (partner→POLR3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAS5 →	+0.811	+0.209	<.001	<.001	3	6
LSCC	EEF1AKNMT →	+0.467	+0.197	<.001	<.001	3	5
UCEC	SETDB1 →	+0.530	+0.207	.002	<.001	3	5
UCEC	NOP56 →	+1.157	+0.300	<.001	<.001	3	5
HNSC	TMEM97 →	+1.295	+0.212	<.001	<.001	3	5
LSCC	DARS2 →	+0.620	+0.264	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,714 associations by consensus.

Exploration

POLR3C survival (RNA) · tumor vs normal (RNA) · all POLR3C data types