Across TCGA patient cohorts, POLR3C mutation is significantly associated with the RNA expression of many other genes, with 590 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3C-associated genes across cancer lineages are MTATP6P20, MIR6817, and MIR548Q. Each is linked with POLR3C in more than 2 cancer types. Because this analysis shows association rather than direction, both POLR3C-to-partner and partner-to-POLR3C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3C→partner) and Y-score (partner→POLR3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTATP6P20 →	+0.162	+5.212	.004	.007	3	3
LUAD	MIR6817 →	+0.731	+5.279	<.001	.006	3	2
BLCA	MIR548Q →	+0.239	+4.147	<.001	.009	3	2
SKCM	LINC00440 →	+0.106	+3.695	<.001	.009	3	2
SKCM	RBPJP5 →	+0.043	+6.225	<.001	<.001	3	2
CESC	PRM2 →	+0.044	+4.539	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 590 associations by consensus.

Exploration

POLR3C survival (RNA) · tumor vs normal (RNA) · all POLR3C data types