POLR3B

Across TCGA patient cohorts, POLR3B protein abundance is significantly associated with the protein abundance of many other proteins, with 11,876 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible POLR3B-associated proteins across cancer lineages are PDS5A_S1305, POLR3C, and POLR3D. Each is linked with POLR3B in more than 4 cancer types. Because this analysis shows association rather than direction, both POLR3B-to-partner and partner-to-POLR3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR3B versus PDS5A_S1305 in PDAC, with a Pearson correlation of 0.43.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3B→partner) and Y-score (partner→POLR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PDS5A_S1305 →	+0.383	+0.346	<.001	<.001	3	5
OV	POLR3C →	+0.354	+0.277	<.001	.003	3	5
BRCA	POLR3D →	+0.432	+0.397	<.001	<.001	3	5
BRCA	MRPL47 →	+0.400	+0.282	<.001	<.001	3	5
OV	ORC2 →	+0.370	+0.261	<.001	<.001	3	5
BRCA	PARN →	+0.351	+0.347	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,876 associations by consensus.

POLR3B vs PDS5A_S1305 — PDAC

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