POLR3A

Across TCGA cell cohorts, POLR3A mutation is significantly associated with the RNA expression of many other genes, with 330 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR3A-associated genes across cancer lineages are CCR8, LRIT2, and C16orf90. Each is linked with POLR3A in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3A-to-partner and partner-to-POLR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by POLR3A-low versus POLR3A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3A→partner) and Y-score (partner→POLR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	2
URINARY_TRACT	LRIT2 →	+0.036	+5.087	<.001	.004	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
SOFT_TISSUE	TSPY2 →	+0.016	+4.369	.001	.008	3	1
SOFT_TISSUE	SERPINB11 →	+0.855	+4.222	<.001	.007	3	1
SOFT_TISSUE	TSPY8 →	+0.016	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 330 associations by consensus.

CCR8 by POLR3A expression — SOFT_TISSUE

Explore this box plot interactively →