POLR2M

Across TCGA patient cohorts, POLR2M mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2M-associated genes across cancer lineages are ERK2, Fibronectin, and JNK_pT183_Y185. Each is linked with POLR2M in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2M-to-partner and partner-to-POLR2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by POLR2M-low versus POLR2M-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2M→partner) and Y-score (partner→POLR2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.202	+3.459	.011	.005	3	1
UCEC	Fibronectin →	-0.277	-2.575	.042	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.185	-2.459	.007	.019	3	1
UCEC	JNK2 →	+0.251	+3.196	.002	.009	3	1
UCEC	MEK1 →	+0.352	+2.459	.019	.019	3	1
UCEC	PCNA →	+0.266	+2.321	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ERK2 by POLR2M expression — UCEC

Explore this box plot interactively →