POLR2M

Across TCGA pan-cancer cohorts, POLR2M RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated POLR2M data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher POLR2M RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR2M expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

UVM, KIRC, and OV are the cancer types where POLR2M RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.170	0.793	<.001	65	view →
KIRC	OS	Quartile	All	0.708	0.507	<.001	49	view →
OV	OS	Quartile	III,IV	0.235	0.374	.008	28	view →
THYM	DFS	Median	II,III,IV	0.946	0.503	.004	24	view →
SCLC	DFS	Median	All	0.535	0.959	.001	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
STAD	DFS	Tertile	III,IV	0.456	0.660	.021	18	view →
KIRP	DFS	Median	IV	0.038	0.527	.010	18	view →
BRCA	DFS	Tertile	III,IV	0.947	0.807	.001	17	view →
DLBC	DFS	Tertile	All	0.708	1.000	.013	14	view →
LUAD	OS	Tertile	All	0.766	0.851	.018	14	view →
HNSC	OS	Quartile	All	0.168	0.498	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

POLR2M–UVM (DFS)

Open the UVM breakdown →