POLR2M

Across TCGA cell cohorts, POLR2M RNA expression is significantly associated with the go_rna of many other GO terms, with 3,384 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR2M-associated GO terms across cancer lineages are Endoplasmic reticulum localization, Transcription elongation by RNA polymerase II, and Endosomal transport. Each is linked with POLR2M in more than 14 cancer types. Because this analysis shows association rather than direction, both POLR2M-to-partner and partner-to-POLR2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum localization grouped by POLR2M-low versus POLR2M-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2M→partner) and Y-score (partner→POLR2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Endoplasmic reticulum localization →	+0.228	+0.934	<.001	.008	2	15
STOMACH	Transcription elongation by RNA polymerase II →	+0.094	+0.738	.005	.006	3	14
STOMACH	Endosomal transport →	+0.055	+0.542	.009	.006	3	12
UPPER_AERODIGESTIVE_TRACT	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.089	+0.997	<.001	<.001	3	12
LARGE_INTESTINE	Positive regulation of mRNA catabolic process →	+0.054	+0.711	<.001	<.001	3	12
BLOOD_Lymphoma	Positive regulation of mRNA metabolic process →	+0.048	+0.828	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,384 associations by consensus.

Endoplasmic reticulum localization by POLR2M expression — LIVER

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