POLR2LP1

Across TCGA pan-cancer cohorts, POLR2LP1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated POLR2LP1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR2LP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2LP1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

HNSC, DLBC, and UCS are the cancer types where POLR2LP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.207	0.437	.001	102	view →
DLBC	DFS	Tertile	II,III,IV	0.070	0.887	<.001	78	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	72	view →
THYM	DFS	Tertile	II,III,IV	0.452	0.953	<.001	54	view →
KICH	DFS	Tertile	All	0.043	0.971	<.001	54	view →
LAML	DFS	Tertile	All	0.185	0.583	.008	36	view →
KIRP	DFS	Median	IV	0.037	0.527	.004	30	view →
SKCM	DFS	Tertile	All	0.722	0.605	.016	21	view →
ESCA	DFS	Tertile	II,III,IV	0.465	0.309	.016	19	view →
LGG	DFS	Tertile	All	0.676	0.845	.004	15	view →
THCA	OS	Tertile	IV	0.832	1.000	.035	9	view →
READ	OS	Tertile	III,IV	0.813	0.435	.044	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

POLR2LP1–HNSC (OS)

Open the HNSC breakdown →