POLR2LP1

Across TCGA pan-cancer cohorts, POLR2LP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of POLR2LP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where POLR2LP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2LP1 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where POLR2LP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2LP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	+0.270	<.001	6	view →
KIRC	All	All	+0.090	.001	5	view →
HNSC	All	All	+0.086	.027	2	view →
BRCA	Female	II,III,IV	−0.060	.023	2	view →
LUAD	All	All	−0.117	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

POLR2LP1–KIRP

Open the KIRP breakdown →