POLR2K

Across TCGA patient cohorts, POLR2K protein abundance is significantly associated with the RNA expression of many other genes, with 6,019 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLR2K-associated genes across cancer lineages are CSF3R, WDR74, and CD180. Each is linked with POLR2K in more than 3 cancer types. Because this analysis shows association rather than direction, both POLR2K-to-partner and partner-to-POLR2K results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR2K versus CSF3R in PDAC, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2K→partner) and Y-score (partner→POLR2K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CSF3R →	-1.008	-0.389	<.001	<.001	3	4
OV	WDR74 →	+0.426	+0.729	.001	.001	3	4
COAD	CD180 →	-0.580	-0.434	<.001	<.001	3	4
LSCC	PIK3R5 →	-0.858	-0.332	<.001	<.001	3	4
LSCC	CD53 →	-0.627	-0.270	<.001	<.001	3	4
LSCC	ANKRD46 →	+0.566	+0.290	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,019 associations by consensus.

POLR2K vs CSF3R — PDAC

Explore this scatter interactively →