POLR2H

Across TCGA pan-cancer cohorts, POLR2H mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of POLR2H’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POLR2H mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2H is over-expressed in tumor.

HNSC, LSCC, and LUAD are the cancer types where POLR2H tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2H mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.547	<.001	11	view →
LSCC	Male	III,IV	+0.923	<.001	9	view →
LUAD	Male	All	+0.677	<.001	9	view →
COAD	Female	All	+0.406	<.001	9	view →
CCRCC	All	III,IV	+0.175	<.001	8	view →
PDAC	All	All	+0.174	.005	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

POLR2H–HNSC

Open the HNSC breakdown →