POLR2H

Across TCGA pan-cancer cohorts, POLR2H RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated POLR2H data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher POLR2H RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2H expression acts as an unfavorable survival marker, although some lineages such as LUSC and DLBC show a favorable association.

LIHC, KICH, and ACC are the cancer types where POLR2H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.611	0.756	<.001	105	view →
KICH	DFS	Median	II,III,IV	0.667	1.000	.001	96	view →
ACC	DFS	Median	All	0.135	0.719	<.001	90	view →
KIRC	DFS	Tertile	All	0.525	0.699	<.001	87	view →
LUAD	OS	Median	III,IV	0.178	0.416	<.001	49	view →
LGG	DFS	Median	All	0.657	0.815	<.001	47	view →
COAD	OS	Median	All	0.755	0.844	.014	27	view →
STAD	DFS	Tertile	IV	0.118	0.861	.003	24	view →
PRAD	DFS	Median	All	0.713	0.878	<.001	24	view →
SKCM	DFS	Tertile	III,IV	0.493	0.875	<.001	23	view →
LUSC	OS	Quartile	All	0.841	0.716	.004	23	view →
ESCA	OS	Tertile	III,IV	0.353	0.680	.004	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

POLR2H–LIHC (OS)

Open the LIHC breakdown →