POLR2H

Across TCGA patient cohorts, POLR2H mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2H-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and Rab11. Each is linked with POLR2H in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2H-to-partner and partner-to-POLR2H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by POLR2H-low versus POLR2H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2H→partner) and Y-score (partner→POLR2H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.144	-3.000	.016	.036	3	1
UCEC	FoxM1 →	+0.289	+2.321	.026	.035	3	1
UCEC	Rab11 →	-0.144	-2.321	.048	.035	3	1
UCEC	Rad50 →	-0.287	-2.321	.018	.035	3	1
UCEC	STAT3_pY705 →	-0.415	-3.169	.001	.018	3	1
UCEC	STAT5a →	+0.412	+3.169	.040	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

A-Raf_pS299 by POLR2H expression — UCEC

Explore this box plot interactively →