POLR2G

Across TCGA patient cohorts, POLR2G mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2G-associated genes across cancer lineages are LINC01050, PRDX3P3, and POTEH-AS1. Each is linked with POLR2G in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2G-to-partner and partner-to-POLR2G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01050 grouped by POLR2G-low versus POLR2G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2G→partner) and Y-score (partner→POLR2G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01050 →	+0.330	+2.958	<.001	.004	3	1
SKCM	PRDX3P3 →	+0.090	+5.097	<.001	.008	3	1
SKCM	POTEH-AS1 →	+0.079	+5.970	<.001	.002	3	1
SKCM	LINC02000 →	+0.093	+5.436	<.001	.005	3	1
HNSC	RNU6-432P →	+0.466	+5.822	<.001	.003	3	1
HNSC	SNORD116-15 →	+0.385	+5.124	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

LINC01050 by POLR2G expression — UCEC

Explore this box plot interactively →