POLR2G

Across TCGA pan-cancer cohorts, POLR2G RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated POLR2G data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher POLR2G RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR2G expression acts as an unfavorable survival marker, although some lineages such as UCEC and CHOL show a favorable association.

ACC, HNSC, and UCEC are the cancer types where POLR2G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.224	0.706	<.001	122	view →
HNSC	DFS	Median	All	0.274	0.425	<.001	106	view →
UCEC	DFS	Median	IV	0.815	0.321	<.001	96	view →
KICH	DFS	Median	II,III,IV	0.558	1.000	.003	90	view →
LIHC	OS	Median	All	0.424	0.582	<.001	89	view →
CESC	OS	Tertile	IV	0.101	0.739	<.001	42	view →
MESO	OS	Tertile	All	0.409	0.644	.008	40	view →
SARC	OS	Tertile	All	0.366	0.621	<.001	33	view →
LGG	DFS	Quartile	All	0.770	0.902	.001	24	view →
KIRC	DFS	Quartile	IV	0.195	0.569	.002	23	view →
KIRP	DFS	Tertile	IV	0.034	0.526	.010	14	view →
LAML	DFS	Median	All	0.465	0.662	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

POLR2G–ACC (DFS)

Open the ACC breakdown →