POLR2G

Across TCGA patient cohorts, POLR2G mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2G-associated genes across cancer lineages are CD8+ Tem, Adipocytes, and Macrophages. Each is linked with POLR2G in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2G-to-partner and partner-to-POLR2G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tem grouped by POLR2G-low versus POLR2G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2G→partner) and Y-score (partner→POLR2G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ Tem →	+0.004	+5.066	<.001	.033	3	1
UCEC	Adipocytes →	+0.021	+2.507	.044	.022	3	1
UCEC	Macrophages →	+0.026	+2.176	.001	.027	3	1
UCEC	Macrophages M2 →	+0.020	+2.831	.001	.035	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ Tem by POLR2G expression — UCEC

Explore this box plot interactively →