POLR2F

Across TCGA pan-cancer cohorts, POLR2F mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POLR2F data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR2F mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2F expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where POLR2F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.693	0.957	.006	11	view →
CCRCC	DFS	Median	III,IV	0.604	0.931	.018	7	view →
LUAD	DFS	Median	All	0.840	0.544	.032	3	view →
PDAC	OS	Median	II,III,IV	0.553	0.238	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POLR2F–HNSC (OS)

Open the HNSC breakdown →