POLR2F

Across TCGA pan-cancer cohorts, POLR2F mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of POLR2F’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where POLR2F mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2F is over-expressed in tumor.

COAD, LUAD, and PDAC are the cancer types where POLR2F tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2F mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.579	<.001	10	view →
LUAD	Female	II,III,IV	+0.683	<.001	9	view →
PDAC	Male	All	+1.287	<.001	6	view →
LSCC	Male	All	+0.540	<.001	5	view →
HNSC	All	All	+0.233	.027	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

POLR2F–COAD

Open the COAD breakdown →