POLR2E

Across TCGA pan-cancer cohorts, POLR2E Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated POLR2E data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR2E Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR2E expression acts as an unfavorable survival marker.

HNSC and LGG are the cancer types where POLR2E Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.170	0.696	.010	18	view →
LGG	OS	Median	All	0.147	0.811	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

POLR2E–HNSC (DFS)

Open the HNSC breakdown →