POLR2E

Across TCGA pan-cancer cohorts, POLR2E RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of POLR2E’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where POLR2E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2E is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where POLR2E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.650	<.001	12	view →
COAD	Female	All	+0.712	<.001	10	view →
KIRP	All	II,III,IV	+0.504	<.001	10	view →
HNSC	Male	All	+0.393	<.001	8	view →
LIHC	All	II,III,IV	+0.617	<.001	7	view →
LUSC	All	II,III,IV	+0.380	<.001	5	view →
BRCA	Female	II,III,IV	−0.357	<.001	4	view →
CHOL	All	All	+0.585	<.001	3	view →
STAD	All	II,III,IV	+0.500	.006	3	view →
UCEC	All	III,IV	+0.403	.039	2	view →
ESCA	All	All	+0.656	.039	1	view →
KICH	All	All	−0.214	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

POLR2E–KIRC

Open the KIRC breakdown →