POLR2E

Across TCGA pan-cancer cohorts, POLR2E mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLR2E data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR2E mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2E expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where POLR2E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.763	0.943	<.001	73	view →
LUAD	OS	Quartile	All	0.973	0.355	.008	8	view →
LSCC	DFS	Median	II,III,IV	0.844	0.553	.016	6	view →
PDAC	DFS	Median	III,IV	0.247	0.448	.033	4	view →
CCRCC	OS	Tertile	All	0.937	1.000	.043	2	view →
GBM	OS	Median	All	0.536	0.262	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLR2E–HNSC (OS)

Open the HNSC breakdown →