POLR2E

Across TCGA patient cohorts, POLR2E mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible POLR2E-associated genes across cancer lineages are MTCO1P35, E2F4P1, and RNU6-902P. Each is linked with POLR2E in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2E-to-partner and partner-to-POLR2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO1P35 grouped by POLR2E-low versus POLR2E-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2E→partner) and Y-score (partner→POLR2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTCO1P35 →	+0.115	+5.003	<.001	.002	3	2
SKCM	E2F4P1 →	+0.082	+3.061	<.001	.002	3	2
BLCA	RNU6-902P →	+0.471	+5.177	<.001	.007	3	1
BLCA	TUBB4BP1 →	+0.269	+6.618	<.001	.001	3	1
BLCA	MTND4P33 →	+0.070	+5.899	<.001	.002	3	1
BLCA	CYP2C60P →	+0.456	+5.411	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

MTCO1P35 by POLR2E expression — SKCM

Explore this box plot interactively →